For doses of up to 30 mg, no negative side effects have so far been reported. However this applies only to natural coenzyme Q10, which is produced by fermentation and therefore exhibits the coenzyme's natural structure (trans-conformation). Synthetic versions of the coenzyme exhibit a different structure (cis-confirmaton), so the research undertaken with the natural version cannot necessarily be applied to the synthetic version.
Caution is advised for patients taking blood-thinning medication. Because coenzyme Q10 also influences blood clotting, supplements containing the coenzyme should only be taken in consultation with a doctor or subject to the results of a series of prothrombin time (PT) tests conducted at short intervals at the start of the course. Nonetheless it is precisely the age group 50+ where this type of medication is most common for whom a long-term course of coenzyme Q10 can be especially beneficial.
- Gröber, Uwe: Orthomolekulare Medizin, 3. Aufl. 2008
- Reglin, Felicitas: Wechselwirkungen zwischen Arzneimitteln und Mikronährstoffen. Ralf Reglin Verlag 2009
- Schmidt, Edmund; Schmidt, Nathalie: Leitfaden Mikronährstoffe. Orthomolekulare Prävention und Therapie. Urban & Fischer bei Elsevier 2004